I hope it does not try to cram so much into a single film as was the case with the SPEED RACER film, underm54 mentioned. There were elements from too many episodes to do justice to even one of them.
I likewise hope that they do not do an origin story, because it seems evident from the 2009 film that this is just not the type of thing that families in the US will want their kids to see. If they included a very brief flashback that came well after a whole lot of positive, happy content, maybe. But I really doubt that anything resembling the 2009 film would be popular. Besides that, it will need to overcome the 2009 film's horror of kid tossed out by father, etc, abused by showman, etc., memory that is likely still in the minds of many parents.
The B&W series mixed humor with the serious content in a cartoony way that outweighed the negative content. The doughnut eaten by bites and removed in one piece good as new, Tenma bouncing down the stairs on his head, etc., & very little on Tobio, plus Fred Ladd was eager for a Pinocchio - type story likely saved the show, or, at least the 1st episode. Consider the 1980 version, its version of the origin was cut to pieces. Anyway, the origin story was considered inappropriate for U.S. kids, & the 2003 series put it at the series' end, perhaps for that reason.
If they start with Atom going to school, accepted by other kids, etc., then something adventurous happens, maybe a chance for a success; yet, the expectations established by the 2009 film will still be an obstacle.